Friday, September 1, 2006

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.

Thursday, June 19, 2008

Buffalo, New York — Judge Justice Christopher Burns of the New York State Supreme Court has ordered a halt to an emergency demolition on a 19th century stable and livery on 428-430 Jersey Street in Buffalo, New York that partially collapsed on Wednesday June 11, initially causing at least 15 homes to be evacuated. At least two homes remain evacuated.

Burns orders that both the city and the group Save The Livery (www.savethelivery.com) have to come to an agreement on what to do with the building, and try to work out ways of saving at least some portions if it including the facade, side walls and a lift tower. Save The Livery is comprised of concerned area residents who have grown to love the building’s historic and unique character. On June 14, they won a temporary restraining order to stop demolition. The court ruled that the city was only allowed to remove material in immediate danger to residents and pedestrians, but stated that the demolition could only be performed with “hand tools.” The court also ordered that any rubble which had fallen into neighboring yards when the building collapsed, to be removed.

“It is in the interest of the city to have a safe environment–but also important to maintain a sense of historical preservation,” stated Burns in his ruling. Burns has given the sides until tomorrow (Friday June 20) to come to an agreement and has ordered both parties to return to court at 9:30 a.m. (eastern time) “sharp.” Activists of Save The Livery urge supporters of the stable to “fill the courtroom” to show “continued and ongoing support.” The hearing is scheduled to take place at 25 Delaware Avenue in the Supreme Court building, 3rd Floor, trial part 19.

Currently the building is owned by Bob Freudenheim who has several building violations against him because of the buildings poor condition. He has received at least five violations in three months and residents who live near the building state that Freudenheim should be “100% responsible” for his actions. Many are afraid that if the building is demolished, Freudenheim’s charges of neglect will be abolished.

On June 17, developer and CEO of Savarino Companies, Sam Savarino was at the site of the stable, discussing the building with residents and preservationists. In 2006, Savarino proposed and planned The Elmwood Village Hotel, a ‘botique’ hotel on the Southeast corner of Elmwood and Forest Avenues. The project was later withdrawn after residents filed a lawsuit against Savarino and the city. Wikinews extensively covered the story, and contacted Savarino for his professional opinion on the building.

“[I would] love to see it preserved. I was there to see if there was anything we could do to help, to see if anything can be salvaged. I just want to see the right thing happen, and so does the city,” stated Savarino to Wikinews who added that he was allowed inside the building for a brief period.

“The side walls are beyond repair. The roof has rotted and it could come down at any time,” added Savarino who also said that the building “below the second floor appears to be stable.” He also states that the back wall of the building, which borders several homes, appears to be intact.

“Eliminating the back wall could be a problem for the neighbors. It is not unreasonable to leave at least 12 feet” of the back wall standing, added Savarino.

Savarino did not say if he was interested in buying the property, but did state, “I am sure there are a couple of people interested” in buying the property. On Thursday, Buffalo News reported that a “businessman” might be interested in purchasing the property, though Wikinews is not able to independently confirm the report. Savarino says that with the property still slated for emergency demolition, a potential buyer could face tax fees of nearly US$300,000.

Freudenheim gave the city permission to demolish the building on Thursday June 12 during an emergency Preservation Board meeting, because he would not be “rehabilitating the building anytime soon.” Freudenheim, along with his wife Nina, were part-owners of the Hotel Lenox at 140 North Street in Buffalo and were advocates to stop the Elmwood Village Hotel. They also financially supported a lawsuit in an attempt to stop the hotel from being built. Though it is not known exactly how long Freudenheim has owned the stable, Wikinews has learned that he was the owner while fighting to stop the hotel from being built. Residents say that he has been the owner for at least 22 years.

The building was first owned by a company called White Bros. and was used as a stable for a farm which once covered the land around the building for several blocks. The Buffalo Fire Department believes the building was built around 1814, while the city property database states it was built in 1870. Servants and workers of the farm were housed inside resident quarters situated at the rear of the building on what is now Summer Street, but are now cottages where area residents currently reside. Some date as far back as 1829.

At about 1950, the stable was converted into an automobile body shop and gasoline station.A property record search showed that in 1950 at least four fuel storage tanks were installed on the property. Two are listed as 550 square feet while the other two are 2,000 square feet. All of the tanks are designated as a TK4, which New York State says is used for “below ground horizontal bulk fuel storage.” The cost of installing a tank of that nature according to the state, at that time, included the tank itself, “excavation and backfill,” but did not include “the piping, ballast, or hold-down slab orring.” It is not known if the tanks are still on the property, but residents are concerned the city was not taking the precautions to find out.

Saturday, April 5, 2008

The family of the 19 year old who was ‘murdered’ in a pub car park two days ago have made a statement regarding the death of their child. They said that “Jack is obviously dearly missed by all of his family. He was a much loved son and brother.”

“Nothing can ever fill the hole that has been left in our lives,” they continued. “We know that Jack had a lot of friends, but we have been amazed by the amount of messages that people have left. “

The family continued “we can not believe Jack has gone, we all keep expecting him to walk back in. Jack was an angel, he was amazing.”

The death, which was treated as murder, resulted in two arrests. The murder, which occurred on Wednesday evening, took place near Highridge Road in Bishopsworth, Bristol.

Tuesday, April 14, 2009

The Red River at Winnipeg is almost clear of ice blocks and ice jamming, however there are still dangers from the Red River flood.

Ice blocks which were as high as two storey buildings were ripping out trees, fences and railway ties. “You’ll see huge pans of ice standing vertical, up to 20 feet (6.1 m) high,” said Steve Topping, an official with the provincial Water Stewardship Department. “Ice was shoved up on the shore and took out trees with a very devastating effect. It has changed people’s view of the river.”

“It is incredible, the force. One piece of ice pushed out of the river about 20 feet. You watch the force push this up right in front of your eyes,” said Dean North, of the Selkirk Golf and Country Club.

Royal Canadian Mounted Police are ticketing sight seers who are driving through road closure signs and approaching excavators, cranes and crews breaking up the ice. Vehicles, people, boats, and kayaks are getting in the way.

An eight year old boy is in critical condition after slipping on a culvert Thursday. He was pulled underwater by the speed of the flowing water and remained under for about five to ten minutes until adults could rescue him. The air ambulance supplied by Alberta’s STARS (Shock Trauma Air Rescue Society) remains in the city of Winnipeg, Manitoba.

“This is not a spectator sport. It’s not about getting the best pictures for the family albums. I know floods are seen as a bit of an event, but some of the instances I’m hearing about, people should give their head a shake, they really should,” said Steve Ashton Manitoba Emergency Measures Minister, “Those who fall into the river or get into trouble in another way would be not only endangering themselves but the emergency response crews trying to rescue them. I don’t want to see a situation … where we’re trying our darndest to prevent flooding and save lives and somebody [who] decides to go have a white-water experience ends up killing themselves.”

Early Easter Sunday morning floodwater reached the rural municipalities of St. Andrews and St. Clements north of Winnipeg. Residents were sent an evacuation advisory Good Friday, however some residents remained. Rescue efforts commenced Saturday night to find those stranded and unable to leave as their vehicles cannot travel in the swollen overland floodwaters. Some people were rescued from roof tops as entire houses were swept off of their foundations by the large ice blocks hurtling down the river.

Highways in the area remain closed. Neil Gobelle, of Manitoba Infrastructure and Transportation said to “definitely continue to watch the Red River Valley and north of the city up in the Selkirk area. Things are changing quite a bit, quite quickly, so we’ll keep an eye on those areas.”

As of Easter Sunday, Winnipeg is expected to be ice free on the Red River. The River rose 4 feet (1.2 m) in the course of 24 hours. Rain is in the forecast and the higher temperatures of 17 °C (62.6 °F) will cause melting of snow and ice.

A weather system caused by La Niña is being watched by the United States National Weather Service and its potential effects between April 16-18 for residents along the Red River Valley. “We want people to be aware there is a very real possibility of the river going higher than what is out there,” said Mark Ewens, data manager at the NWS, “To have spring floods like this back-to-back is just an unfortunate series of events that have come along to plague us this spring. We’re wanting people to understand that this is a potentially serious problem.”

Wednesday, June 12, 2013

A two-vehicle road traffic accident in County Donegal in Ireland has left one person dead and injured two others. The accident occurred when a camper van collided with an oncoming car on the N15 road between the towns of Ballybofey and Donegal at approximately 1540 BST (1440 UTC) on Monday.

The fatality was reportedly a man in his 70s from the town of Lifford; he has not yet been publicly identified. He was taken to Letterkenny General Hospital, where he was pronounced dead. The female passenger he was travelling in the car with, thought to be the wife of the man, was taken to the same hospital after suffering serious injuries.

The man and woman in the camper van were transported to Sligo Regional Hospital. The condition of the two occupants is not clear, although the woman in the vehicle reportedly injured her leg in the accident.

The road where the crash occurred was closed to allow the Garda to investigate the incident.